Positive regulation of calcium-mediated signaling

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, PAK6, and CXXC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium-mediated signaling activity versus TTK in LUNG_NSCLC_LUSC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TTK →	+0.921	+0.243	<.001	<.001	3	4
STOMACH	PAK6 →	+1.576	+0.204	.006	.004	3	4
LARGE_INTESTINE	CXXC5 →	-1.357	-0.112	.007	.007	3	4
BLOOD_Leukemia	SGPP1 →	+1.332	+0.170	.003	.003	3	4
BLOOD_Leukemia	FAM102B →	+0.942	+0.149	.001	.008	3	4
LIVER	DDI2 →	-0.799	-0.176	.009	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050850 vs TTK — LUNG_NSCLC_LUSC

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