Negative regulation of calcium-mediated signaling

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium-mediated signaling pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNFAIP8, WAS, and DEF6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium-mediated signaling activity versus TNFAIP8 in GBM (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNFAIP8 →	+0.646	+0.067	<.001	<.001	3	9
GBM	WAS →	+0.500	+0.061	<.001	<.001	3	8
CCRCC	DEF6 →	+0.531	+0.055	<.001	<.001	3	8
CCRCC	DOCK10 →	+0.440	+0.049	<.001	<.001	3	8
GBM	FMNL1 →	+0.509	+0.060	<.001	<.001	3	8
LSCC	FMNL1_S1031 →	+0.630	+0.067	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050849 vs TNFAIP8 — GBM

Explore this scatter interactively →