Negative regulation of calcium-mediated signaling

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRAG1, ITPR1, and MYLK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium-mediated signaling activity versus IRAG1 in LSCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IRAG1 →	+0.561	+0.213	<.001	.002	3	6
LSCC	ITPR1 →	+0.545	+0.337	<.001	<.001	3	5
LSCC	MYLK →	+0.730	+0.349	<.001	<.001	3	5
LSCC	MEF2C →	+0.475	+0.295	.009	.004	3	5
OV	UNC5C →	+0.567	+0.143	.002	.004	3	4
OV	FAT4 →	+0.441	+0.135	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050849 vs IRAG1 — LSCC

Explore this scatter interactively →