Negative regulation of calcium-mediated signaling

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARPC2, CASKIN1, and CD44, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium-mediated signaling activity versus ARPC2 in BLOOD_Lymphoma (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARPC2 →	+1.089	+1.634	.001	<.001	3	5
BLOOD_Lymphoma	CASKIN1 →	-1.296	-1.109	.005	<.001	3	5
OVARY	CD44 →	+2.586	+0.910	.006	.005	3	5
LUNG_SCLC	RAVER2 →	-1.084	-1.137	<.001	<.001	3	5
LIVER	NRDC →	+0.689	+1.873	.004	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	FAM53B →	-0.768	-1.251	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050849 vs ARPC2 — BLOOD_Lymphoma

Explore this scatter interactively →