Regulation of calcium-mediated signaling

Across TCGA patient cohorts, RNA activity of the Regulation of calcium-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD53, FCRL6, and CSF2RB, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium-mediated signaling activity versus CD53 in SKCM (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CD53 →	+2.331	+0.055	<.001	<.001	3	32
CHOL	FCRL6 →	+1.413	+0.072	<.001	<.001	3	32
SKCM	CSF2RB →	+1.886	+0.055	<.001	<.001	3	31
SKCM	PLA2G2D →	+2.810	+0.047	<.001	<.001	3	31
CHOL	THEMIS2 →	+2.124	+0.064	<.001	<.001	3	31
SCLC	CCR5 →	+2.448	+0.148	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050848 vs CD53 — SKCM

Explore this scatter interactively →