Regulation of calcium-mediated signaling

Across TCGA patient cohorts, RNA activity of the Regulation of calcium-mediated signaling pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1_S351, ARRB2, and SASH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium-mediated signaling activity versus RCSD1_S351 in LSCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCSD1_S351 →	+0.631	+0.053	<.001	<.001	3	10
UCEC	ARRB2 →	+0.366	+0.055	<.001	.001	3	10
GBM	SASH3 →	+0.556	+0.066	<.001	<.001	3	10
OV	SKAP2 →	+0.792	+0.052	<.001	<.001	3	10
LSCC	STK10 →	+0.422	+0.059	<.001	<.001	3	10
LSCC	THEMIS2_T593 →	+0.828	+0.060	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050848 vs RCSD1_S351 — LSCC

Explore this scatter interactively →