Regulation of calcium-mediated signaling

Across TCGA patient cohorts, RNA activity of the Regulation of calcium-mediated signaling pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK10_S1257, ITPR1_S1598, and ZC3H14_S620, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium-mediated signaling activity versus DOCK10_S1257 in LUAD (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DOCK10_S1257 →	+0.846	+0.193	<.001	<.001	3	6
BRCA	ITPR1_S1598 →	+0.840	+0.228	<.001	<.001	3	6
LUAD	ZC3H14_S620 →	-0.972	-0.198	<.001	<.001	3	5
OV	EVL_S331 →	+0.676	+0.215	<.001	<.001	3	5
LUAD	FOXK1_S223 →	-0.900	-0.215	<.001	<.001	3	5
LSCC	GMPS →	-0.509	-0.232	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050848 vs DOCK10_S1257 — LUAD

Explore this scatter interactively →