Regulation of calcium-mediated signaling

Across TCGA cell cohorts, RNA activity of the Regulation of calcium-mediated signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A43, CLDN23, and EPS15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A43 grouped by Regulation of calcium-mediated signaling-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SLC25A43 →	+0.144	+1.258	.001	<.001	3	4
LUNG_NSCLC_LUSC	CLDN23 →	-0.477	-1.474	.003	.008	3	4
PANCREAS	EPS15 →	-0.145	-0.797	<.001	.004	3	3
STOMACH	MAD2L1 →	+0.411	+0.854	.004	.006	2	4
KIDNEY	SSTR2 →	+0.198	+0.885	<.001	.002	3	3
LUNG_NSCLC_LUSC	KDM4E →	+0.223	+1.402	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A43 by Regulation of calcium-mediated signaling activity — KIDNEY

Explore this box plot interactively →