Regulation of calcium-mediated signaling

Across TCGA cell cohorts, RNA activity of the Regulation of calcium-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIGD1, ACTB, and MYH9, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium-mediated signaling activity versus TIGD1 in BONE (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TIGD1 →	-1.113	-0.150	<.001	<.001	3	12
BONE	ACTB →	+1.202	+0.193	<.001	<.001	3	11
BONE	MYH9 →	+2.803	+0.193	<.001	<.001	3	10
BONE	RCAN1 →	+2.694	+0.148	<.001	<.001	3	10
BONE	PXDC1 →	+2.255	+0.127	<.001	<.001	3	10
STOMACH	MARS2 →	-0.789	-0.098	.004	.002	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050848 vs TIGD1 — BONE

Explore this scatter interactively →