Regulation of calcium-mediated signaling

Across TCGA cell cohorts, RNA activity of the Regulation of calcium-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL4C, NPAT, and MAML1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium-mediated signaling activity versus ARL4C in KIDNEY (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ARL4C →	+1.462	+0.342	.008	.005	3	4
LUNG_NSCLC_LUSC	NPAT →	+1.279	+0.296	.001	.006	3	4
LARGE_INTESTINE	MAML1 →	-0.607	-0.118	<.001	.006	3	4
OVARY	TAF11 →	-0.739	-0.199	<.001	.009	3	4
LUNG_NSCLC_LUSC	NUSAP1 →	+1.181	+0.205	.004	.009	3	4
LUNG_NSCLC_LUSC	DPY19L4 →	+0.356	+0.220	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050848 vs ARL4C — KIDNEY

Explore this scatter interactively →