Defense response to Gram-positive bacterium

Across TCGA patient cohorts, RNA activity of the Defense response to Gram-positive bacterium pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PELATON, LILRB2, and NCF2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Defense response to Gram-positive bacterium activity versus PELATON in GBM (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PELATON →	+0.664	+0.179	<.001	<.001	3	9
GBM	LILRB2 →	+0.879	+0.278	<.001	<.001	3	9
GBM	NCF2 →	+0.831	+0.279	<.001	<.001	3	8
OV	FCGR2A →	+1.113	+0.290	.002	.002	3	8
OV	FCER1G →	+0.971	+0.326	.007	<.001	3	8
GBM	C3AR1 →	+0.693	+0.268	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050830 vs PELATON — GBM

Explore this scatter interactively →