Defense response to Gram-positive bacterium

Across TCGA cell cohorts, RNA activity of the Defense response to Gram-positive bacterium pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPST1, HLA-A, and HLA-B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Defense response to Gram-positive bacterium activity versus TPST1 in URINARY_TRACT (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TPST1 →	+1.669	+0.429	.008	.005	3	7
BREAST	HLA-A →	+2.495	+0.605	.007	.009	2	7
LIVER	HLA-B →	+4.990	+0.494	<.001	<.001	3	6
SKIN	B2M →	+1.597	+0.211	.002	.001	3	5
LIVER	SH2D3A →	-2.268	-0.477	.001	.005	3	5
URINARY_TRACT	PSMB9 →	+3.819	+0.498	.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050830 vs TPST1 — URINARY_TRACT

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