Regulation of acyl-CoA biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of acyl-CoA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICALL1, KLHL5, and ERO1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of acyl-CoA biosynthetic process activity versus MICALL1 in SOFT_TISSUE (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MICALL1 →	-0.956	-0.229	.003	.008	2	6
SOFT_TISSUE	KLHL5 →	-1.380	-0.458	.002	<.001	3	5
KIDNEY	ERO1A →	-1.385	-0.177	<.001	.004	3	5
OVARY	TAGLN →	-3.836	-0.231	.001	.007	3	5
BONE	NDST1 →	-2.152	-0.453	<.001	.003	2	6
LUNG_SCLC	EPAS1 →	-1.825	-0.144	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050812 vs MICALL1 — SOFT_TISSUE

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