Regulation of steroid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of steroid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEXN, S1PR1, and PABPC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of steroid biosynthetic process activity versus NEXN in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NEXN →	+0.635	+0.133	.002	.001	3	5
BRCA	S1PR1 →	+0.453	+0.172	.004	<.001	3	5
BRCA	PABPC5 →	+0.594	+0.198	<.001	.004	3	5
GBM	DAB2 →	+0.793	+0.142	<.001	.008	3	5
PDAC	MMP19 →	+0.561	+0.113	.001	.004	3	5
PDAC	PDLIM3 →	+0.583	+0.095	.005	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050810 vs NEXN — BRCA

Explore this scatter interactively →