Regulation of steroid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of steroid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IPP, ERLIN2, and PPIL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of steroid biosynthetic process activity versus IPP in KIDNEY (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IPP →	+1.109	+0.323	<.001	.004	3	6
BLOOD_Leukemia	ERLIN2 →	+1.375	+0.317	<.001	<.001	3	6
LUNG_NSCLC_LUSC	PPIL2 →	+0.876	+0.258	<.001	<.001	3	5
SOFT_TISSUE	WDR45 →	-0.688	-0.275	<.001	.005	3	5
BLOOD_Leukemia	EHHADH →	+1.203	+0.186	.001	.001	3	5
URINARY_TRACT	CTNNBL1 →	-0.795	-0.176	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050810 vs IPP — KIDNEY

Explore this scatter interactively →