Positive regulation of synaptic transmission

Across TCGA cell cohorts, RNA activity of the Positive regulation of synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINB6, SOX13, and MTERF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synaptic transmission activity versus SERPINB6 in BLOOD_Leukemia (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SERPINB6 →	+2.722	+0.968	.001	.003	3	4
SKIN	SOX13 →	+1.376	+0.255	.002	.001	3	4
BLOOD_Lymphoma	MTERF1 →	-1.537	-1.051	.004	.002	3	3
BLOOD_Lymphoma	SIRT2 →	+0.814	+1.106	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	SERPINE2 →	+2.072	+1.277	.007	.002	3	3
LUNG_SCLC	ACVR1 →	+1.289	+0.197	.001	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050806 vs SERPINB6 — BLOOD_Leukemia

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