Negative regulation of synaptic transmission

Across TCGA cell cohorts, RNA activity of the Negative regulation of synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDH3, ESRP1, and ZEB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of synaptic transmission activity versus CDH3 in SOFT_TISSUE (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CDH3 →	+0.945	+0.465	.001	.002	3	6
LUNG_NSCLC_LUSC	ESRP1 →	+4.594	+0.248	.001	.002	3	5
LUNG_NSCLC_LUSC	ZEB1 →	-3.305	-0.324	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	THAP12 →	+2.074	+0.262	.004	.006	3	4
KIDNEY	SLC30A9 →	+0.541	+0.136	.005	.002	3	4
LUNG_NSCLC_LUSC	GALNT3 →	+5.404	+0.331	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050805 vs CDH3 — SOFT_TISSUE

Explore this scatter interactively →