Regulation of insulin secretion

Across TCGA cell cohorts, RNA activity of the Regulation of insulin secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEX2, SLC24A1, and OCEL1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEX2 grouped by Regulation of insulin secretion-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TEX2 →	+0.676	+0.131	.001	.004	3	3
LUNG_NSCLC_LUSC	SLC24A1 →	+0.838	+0.235	.002	.001	3	3
LUNG_NSCLC_LUSC	OCEL1 →	+1.326	+0.231	<.001	<.001	3	3
SOFT_TISSUE	TGFBR1 →	+1.353	+0.715	.004	.009	3	3
KIDNEY	TIMM8B →	-0.720	-0.765	.008	.003	3	3
CNS	ITPR2 →	+1.091	+0.142	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEX2 by Regulation of insulin secretion activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →