Regulation of behavior

Across TCGA patient cohorts, RNA activity of the Regulation of behavior pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAP, C1R, and PRR14_T363, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of behavior activity versus FAP in COAD (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FAP →	+0.755	+0.021	.001	<.001	3	6
CCRCC	C1R →	+0.449	+0.035	.006	.001	3	5
BRCA	PRR14_T363 →	+0.625	+0.016	.007	.004	3	5
LSCC	RNASE1 →	+0.409	+0.022	<.001	<.001	3	5
OV	AJUBA_S79 →	-0.862	-0.028	.001	.007	3	4
OV	APOE →	+0.641	+0.032	.009	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050795 vs FAP — COAD

Explore this scatter interactively →