Regulation of behavior

Across TCGA cell cohorts, RNA activity of the Regulation of behavior pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPA1, MCUR1, and TUBG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of behavior activity versus RPA1 in PANCREAS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RPA1 →	+0.722	+0.428	.005	.001	3	4
SKIN	MCUR1 →	+0.785	+0.311	<.001	.001	3	4
BLOOD_Leukemia	TUBG1 →	+0.909	+0.287	<.001	<.001	3	4
BLOOD_Leukemia	ZBED3 →	+1.227	+0.174	<.001	.003	3	4
BLOOD_Leukemia	CFB →	+0.532	+0.250	.005	.001	3	4
BLOOD_Leukemia	RBBP7 →	+0.523	+0.207	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050795 vs RPA1 — PANCREAS

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