RNA destabilization

Across TCGA patient cohorts, RNA activity of the RNA destabilization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MESD, BAZ2B, and MRPL46, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA destabilization activity versus MESD in BRCA (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MESD →	-0.608	-0.316	<.001	<.001	3	2
BRCA	BAZ2B →	-0.622	-0.265	.002	.004	3	2
BRCA	MRPL46 →	-0.526	-0.308	<.001	<.001	3	2
BRCA	ARID4A →	-0.691	-0.334	.003	<.001	3	2
BRCA	YPEL3 →	-1.513	-0.315	.002	.005	3	2
COAD	PURPL →	-1.028	-0.167	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050779 vs MESD — BRCA

Explore this scatter interactively →