Q-omics provides the consensus-scored PURPL profile across patient tissues and cancer cell-line models. PURPL expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, PURPL is differentially expressed in 7, with the highest sampling consensus in HNSC. Additionally, PURPL RNA expression shows 12,160 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight UVM, HNSC, and THYM as cancer lineages where PURPL shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PURPL — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PURPL survival associations across molecular data types. PURPL RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PURPL RNA expression–survival associations across cancer types. High PURPL expression shows unfavorable associations in UVM, OV, LGG, BRCA and KIRP, but favorable associations in UCS. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for PURPL RNA expression.
This table summarizes PURPL tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for PURPL. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PURPL shows higher tumor expression in HNSC, LIHC, COAD, STAD, LUAD and THCA. The HNSC box plot shows higher PURPL RNA expression in tumor versus normal tissue (log2 FC = +0.389, t-test p < 0.001).
This table shows molecular features associated with PURPL in patient tissues and cancer cell lines. In patient samples, PURPL shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
