PURPL

Across TCGA patient cohorts, PURPL RNA expression is significantly associated with the mutation status of many other genes, with 9,106 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PURPL-associated genes across cancer lineages are TP53, NSD1, and ADGRV1. Each is linked with PURPL in more than 8 cancer types. Because this analysis shows association rather than direction, both PURPL-to-partner and partner-to-PURPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by PURPL-low versus PURPL-high in SKCM.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PURPL→partner) and Y-score (partner→PURPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TP53 →	-2.395	-1.143	<.001	<.001	3	9
LUSC	NSD1 →	+2.378	+1.135	<.001	<.001	3	3
LIHC	ADGRV1 →	+1.933	+0.611	.002	.002	3	3
UCEC	DYSF →	+1.310	+0.439	<.001	<.001	3	3
UCEC	DCHS2 →	+1.136	+0.395	<.001	<.001	3	3
UCEC	VPS13A →	+1.404	+0.379	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,106 associations by consensus.

TP53 by PURPL expression — SKCM

Explore this box plot interactively →