Regulation of axonogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of axonogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNPY4, FKBP10, and FKBP9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of axonogenesis activity versus CNPY4 in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNPY4 →	+0.376	+0.020	<.001	<.001	3	7
LSCC	FKBP10 →	+0.659	+0.033	<.001	.001	3	6
LSCC	FKBP9 →	+0.551	+0.041	<.001	<.001	3	6
LSCC	MAP1A →	+0.357	+0.025	<.001	<.001	3	6
OV	HEG1 →	+0.426	+0.034	.003	.002	3	6
LSCC	SERPINH1 →	+0.443	+0.029	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050770 vs CNPY4 — BRCA

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