Regulation of axonogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of axonogenesis pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 157 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Regulation of axonogenesis pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and LUAD, show the opposite pattern, with higher activity associated with better survival.

HNSC, LIHC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.397	0.247	<.001	119	view →
LIHC	DFS	Median	All	0.438	0.608	<.001	88	view →
ACC	DFS	Tertile	All	0.311	0.614	.002	48	view →
LUAD	OS	Median	III,IV	0.635	0.379	<.001	44	view →
ESCA	OS	Quartile	III,IV	0.868	0.312	<.001	30	view →
KIRP	OS	Median	All	0.531	0.776	.001	28	view →
KIRC	DFS	Median	II,III,IV	0.396	0.617	.004	25	view →
KICH	OS	Median	All	0.831	0.960	.011	21	view →
UCS	OS	Quartile	II,III,IV	1.000	0.214	.003	20	view →
SCLC	OS	Median	II,III,IV	0.978	0.443	.012	19	view →
BRCA	DFS	Quartile	III,IV	0.945	0.809	.016	10	view →
READ	DFS	Tertile	II,III,IV	0.672	0.354	.034	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0050770–HNSC (DFS)

Open the HNSC breakdown →