Regulation of axonogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of axonogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNN1, TPM1, and DPYSL3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of axonogenesis activity versus CNN1 in OV (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CNN1 →	+1.866	+1.160	.001	.005	3	3
BRCA	TPM1 →	+0.947	+1.209	.001	<.001	3	3
BRCA	DPYSL3 →	+1.280	+1.164	.001	.002	3	3
BRCA	POSTN →	+1.387	+1.140	.003	.001	3	3
BRCA	NTM →	+1.057	+1.420	<.001	<.001	3	3
OV	VEGFD →	+0.390	+1.064	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050770 vs CNN1 — OV

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