Regulation of axonogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of axonogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRGPRX1, C9orf85, and IFI30, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRGPRX1 grouped by Regulation of axonogenesis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MRGPRX1 →	-0.229	-0.212	.004	.001	3	5
STOMACH	C9orf85 →	-0.178	-0.205	.004	.004	3	4
STOMACH	IFI30 →	-0.279	-0.298	.002	<.001	3	4
BREAST	APOC2 →	-0.092	-0.130	.003	<.001	3	4
BONE	RGS10 →	-0.290	-0.424	.002	<.001	3	4
LUNG_NSCLC_LUAD	ITGB6 →	-0.193	-0.485	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRGPRX1 by Regulation of axonogenesis activity — OESOPHAGUS

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