Regulation of axonogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of axonogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZCRB1, SRPX2, and RAI14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZCRB1 grouped by Regulation of axonogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZCRB1 →	+0.455	+0.238	.005	.002	3	3
LIVER	SRPX2 →	-2.818	-1.239	.002	.004	3	3
LIVER	RAI14 →	-1.691	-1.263	<.001	.002	3	3
PANCREAS	BARD1 →	+0.577	+0.205	.001	<.001	3	3
BLOOD_Leukemia	TBP →	+0.594	+1.304	.002	<.001	3	3
BLOOD_Leukemia	LATS1 →	+0.920	+0.959	.007	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZCRB1 by Regulation of axonogenesis activity — LUNG_SCLC

Explore this box plot interactively →