Regulation of axonogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of axonogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAP1, PRMT3, and MARS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of axonogenesis activity versus TRAP1 in SKIN (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TRAP1 →	-0.652	-0.218	.007	.009	2	8
PANCREAS	PRMT3 →	-1.304	-0.328	.001	.005	2	7
OESOPHAGUS	MARS2 →	-1.004	-0.300	.001	.001	2	7
PANCREAS	TWNK →	-0.979	-0.284	.002	.007	2	7
SOFT_TISSUE	TMEM177 →	-1.045	-0.346	.001	.004	3	6
BLOOD_Myeloma	NOP56 →	-1.115	-0.251	<.001	.004	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050770 vs TRAP1 — SKIN

Explore this scatter interactively →