Positive regulation of neurogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of neurogenesis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM43B, SETP9, and YWHAQP4, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neurogenesis activity versus FAM43B in COAD (Pearson r = 0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FAM43B →	-0.252	-0.987	<.001	.006	3	1
COAD	SETP9 →	-0.315	-0.892	<.001	.002	3	1
COAD	YWHAQP4 →	+0.365	+0.123	.005	.004	2	1
COAD	MTND1P9 →	-0.202	-0.933	.008	<.001	2	1
COAD	NFIA-AS1 →	-0.201	-0.715	.006	.008	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest associations by consensus.

GO:0050769 vs FAM43B — COAD

Explore this scatter interactively →