Negative regulation of lipoprotein metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipoprotein metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASPN, PUS7, and ALDH1A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipoprotein metabolic process activity versus ASPN in COAD (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASPN →	+0.980	+0.099	<.001	<.001	3	6
BRCA	PUS7 →	-0.385	-0.060	<.001	<.001	3	6
HNSC	ALDH1A1 →	+0.568	+0.082	.002	.002	3	6
GBM	DCN →	+0.985	+0.119	<.001	<.001	3	6
GBM	MYO1D →	+0.783	+0.093	.002	.002	3	6
GBM	OGN →	+1.432	+0.129	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050748 vs ASPN — COAD

Explore this scatter interactively →