Negative regulation of peptidyl-tyrosine phosphorylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, DOCK2, and FYB1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptidyl-tyrosine phosphorylation activity versus WIPF1 in HNSC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WIPF1 →	+0.417	+0.049	<.001	.002	3	10
GBM	DOCK2 →	+0.634	+0.077	<.001	<.001	3	10
GBM	FYB1 →	+0.671	+0.073	<.001	<.001	3	10
OV	LCP1 →	+0.739	+0.053	<.001	<.001	3	10
OV	ARHGAP25 →	+1.015	+0.112	.006	<.001	3	10
UCEC	IL16 →	+0.661	+0.107	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050732 vs WIPF1 — HNSC

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