Negative regulation of peptidyl-tyrosine phosphorylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP2CA, PPP2R1A, and TSG101, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP2CA grouped by Negative regulation of peptidyl-tyrosine phosphorylation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PPP2CA →	-0.479	-0.268	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	PPP2R1A →	-0.629	-0.258	.003	.002	2	7
LUNG_NSCLC_LUAD	TSG101 →	-0.399	-0.276	.001	<.001	3	5
BONE	SGCB →	+0.389	+0.477	.005	.001	2	5
LARGE_INTESTINE	RNF38 →	+0.224	+0.429	.001	.003	3	4
LUNG_NSCLC_LUAD	SLC4A4 →	+0.145	+0.179	.004	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP2CA by Negative regulation of peptidyl-tyrosine phosphorylation activity — OESOPHAGUS

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