Negative regulation of peptidyl-tyrosine phosphorylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD14, DNAJB1, and MTSS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD14 grouped by Negative regulation of peptidyl-tyrosine phosphorylation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CD14 →	-0.292	-0.136	.006	.001	3	5
CNS	DNAJB1 →	-0.200	-0.092	<.001	<.001	3	5
LUNG_SCLC	MTSS2 →	+0.160	+0.093	<.001	.002	3	5
LUNG_SCLC	CLCN2 →	+0.205	+0.080	.001	.002	3	5
LUNG_NSCLC_LUAD	SLC10A3 →	-0.115	-0.071	.004	<.001	3	5
BONE	MAX →	-0.496	-0.133	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD14 by Negative regulation of peptidyl-tyrosine phosphorylation activity — BONE

Explore this box plot interactively →