Negative regulation of peptidyl-tyrosine phosphorylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPRC5A, DISP1, and KLF9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptidyl-tyrosine phosphorylation activity versus GPRC5A in OVARY (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GPRC5A →	+2.784	+1.285	.002	<.001	3	10
LIVER	DISP1 →	-1.017	-1.632	.009	.003	3	5
BLOOD_Lymphoma	KLF9 →	-1.839	-0.383	.002	.004	1	6
BLOOD_Lymphoma	GPR155 →	-1.517	-0.423	<.001	.002	2	5
PANCREAS	EPAS1 →	-2.005	-1.191	.009	.002	3	4
PANCREAS	KLK5 →	+3.485	+1.213	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050732 vs GPRC5A — OVARY

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