Positive regulation of inflammatory response

Across TCGA cell cohorts, RNA activity of the Positive regulation of inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MR1, PSMB8, and PAXIP1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of inflammatory response activity versus MR1 in LUNG_NSCLC_LUSC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MR1 →	+2.002	+0.124	.002	.001	3	15
SOFT_TISSUE	PSMB8 →	+3.795	+0.108	<.001	<.001	3	15
BLOOD_Lymphoma	PAXIP1 →	-1.043	-0.119	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	APOL1 →	+2.976	+0.098	<.001	<.001	3	14
BLOOD_Lymphoma	URB2 →	-1.151	-0.084	<.001	<.001	3	14
SOFT_TISSUE	SAFB →	-0.900	-0.114	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050729 vs MR1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →