Positive regulation of inflammatory response

Across TCGA cell cohorts, RNA activity of the Positive regulation of inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFP36, NAB1, and ERBIN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of inflammatory response activity versus ZFP36 in KIDNEY (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZFP36 →	-2.219	-0.233	.002	.002	3	4
KIDNEY	NAB1 →	+0.699	+0.173	.005	.003	3	4
LUNG_SCLC	ERBIN →	-1.102	-0.240	.003	.002	3	4
LUNG_SCLC	CITED1 →	+1.548	+0.185	<.001	<.001	3	4
LUNG_SCLC	PARP14 →	-1.858	-0.230	.001	<.001	3	4
LUNG_SCLC	DNAH5 →	-1.068	-0.250	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050729 vs ZFP36 — KIDNEY

Explore this scatter interactively →