Negative regulation of inflammatory response

Across TCGA patient cohorts, RNA activity of the Negative regulation of inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RB, TLR8, and LILRB1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of inflammatory response activity versus IL2RB in SCLC (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	IL2RB →	+2.292	+0.123	<.001	<.001	3	34
LAML	TLR8 →	+3.057	+0.050	<.001	<.001	3	34
LAML	LILRB1 →	+2.014	+0.047	<.001	<.001	3	34
LAML	LILRA1 →	+2.150	+0.047	<.001	<.001	3	34
LAML	SIGLEC9 →	+2.499	+0.053	<.001	<.001	3	34
SCLC	THEMIS2 →	+2.504	+0.112	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050728 vs IL2RB — SCLC

Explore this scatter interactively →