Negative regulation of inflammatory response

Across TCGA patient cohorts, RNA activity of the Negative regulation of inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF14, MYBPC3, and TLR8, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of inflammatory response activity versus TNFSF14 in HNSC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TNFSF14 →	+0.975	+0.208	<.001	<.001	3	8
PDAC	MYBPC3 →	+0.295	+0.094	.005	.003	3	8
GBM	TLR8 →	+0.927	+0.241	<.001	<.001	3	8
GBM	CD37 →	+0.558	+0.180	<.001	<.001	3	8
GBM	WAS →	+0.739	+0.298	<.001	<.001	3	8
OV	RHOH →	+0.743	+0.122	.003	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050728 vs TNFSF14 — HNSC

Explore this scatter interactively →