Negative regulation of inflammatory response

Across TCGA cell cohorts, RNA activity of the Negative regulation of inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TET3, BRSK2, and TTC28, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of inflammatory response activity versus TET3 in LUNG_NSCLC_LUAD (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TET3 →	-0.707	-0.165	.001	.001	3	6
PANCREAS	BRSK2 →	+1.903	+0.220	.001	<.001	3	5
SOFT_TISSUE	TTC28 →	+2.019	+0.333	.002	.005	3	5
STOMACH	USP43 →	-1.490	-0.224	.006	.004	3	5
URINARY_TRACT	IKBIP →	+1.691	+0.406	<.001	<.001	3	5
LUNG_NSCLC_LUSC	B3GNT3 →	-3.917	-0.313	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050728 vs TET3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →