Positive regulation of mRNA processing

Across TCGA patient cohorts, RNA activity of the Positive regulation of mRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBMXL1, DEK, and RNPS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mRNA processing activity versus RBMXL1 in GBM (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RBMXL1 →	+0.375	+0.036	.001	.002	3	6
HNSC	DEK →	+0.390	+0.083	<.001	<.001	3	6
HNSC	RNPS1 →	+0.216	+0.107	<.001	.001	3	5
PDAC	SRSF11 →	+0.211	+0.023	.001	.006	3	5
PDAC	SUPT16H →	+0.318	+0.025	<.001	.008	3	5
HNSC	PHF3 →	+0.217	+0.093	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050685 vs RBMXL1 — GBM

Explore this scatter interactively →