Hydrogen peroxide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Hydrogen peroxide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMG20A_S105, GIMAP8, and UBAP2L_S609, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hydrogen peroxide biosynthetic process activity versus HMG20A_S105 in OV (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HMG20A_S105 →	-0.597	-0.049	.001	.001	3	7
GBM	GIMAP8 →	+0.443	+0.062	<.001	.001	3	6
LUAD	UBAP2L_S609 →	-0.624	-0.074	<.001	<.001	3	6
LUAD	ATAD2_S342 →	-0.802	-0.040	.004	.009	2	7
LSCC	EVL →	+0.363	+0.046	.002	.006	3	6
UCEC	LIN54_S310 →	-0.643	-0.081	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050665 vs HMG20A_S105 — OV

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