Hydrogen peroxide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Hydrogen peroxide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAF3IP3, SLAMF1, and SH2D1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hydrogen peroxide biosynthetic process activity versus TRAF3IP3 in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRAF3IP3 →	+0.968	+0.450	<.001	<.001	3	7
BRCA	SLAMF1 →	+1.144	+0.454	<.001	<.001	3	6
BRCA	SH2D1A →	+1.412	+0.446	<.001	<.001	3	6
GBM	TMEM273 →	+0.800	+0.194	.001	<.001	3	6
LSCC	SLAMF7 →	+1.273	+0.255	<.001	<.001	3	6
GBM	VNN2 →	+0.959	+0.174	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050665 vs TRAF3IP3 — BRCA

Explore this scatter interactively →