Dermatan sulfate proteoglycan metabolic process

Across TCGA patient cohorts, RNA activity of the Dermatan sulfate proteoglycan metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP36_S73, WDR43_S77, and LIG1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dermatan sulfate proteoglycan metabolic process activity versus RRP36_S73 in LSCC (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RRP36_S73 →	-0.658	-0.041	<.001	<.001	3	8
BRCA	WDR43_S77 →	-0.759	-0.033	<.001	<.001	3	8
GBM	LIG1 →	-0.462	-0.052	<.001	<.001	3	8
LUAD	ESF1_S153 →	-0.621	-0.051	<.001	<.001	3	8
GBM	MCM7 →	-0.468	-0.036	<.001	.001	3	8
GBM	MCM5 →	-0.506	-0.038	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050655 vs RRP36_S73 — LSCC

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