Dermatan sulfate proteoglycan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Dermatan sulfate proteoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA4D, ZC3H12D, and PRDX5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dermatan sulfate proteoglycan biosynthetic process activity versus SEMA4D in PDAC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEMA4D →	-0.339	-0.890	<.001	<.001	3	4
CCRCC	ZC3H12D →	-0.438	-0.790	.007	<.001	3	4
LUAD	PRDX5 →	+0.368	+0.255	.003	.008	3	3
LSCC	CFAP300 →	+0.667	+0.721	<.001	.001	3	3
UCEC	SLC2A1 →	+1.005	+1.143	.002	<.001	3	3
LSCC	C10orf95 →	+0.045	+0.610	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050651 vs SEMA4D — PDAC

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