Arachidonic acid secretion

Across TCGA patient cohorts, RNA activity of the Arachidonic acid secretion pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, GVINP1, and CRTAM, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arachidonic acid secretion activity versus PLA2G4A in COAD (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLA2G4A →	+1.870	+0.324	<.001	<.001	3	7
PDAC	GVINP1 →	+0.423	+0.147	.003	.002	3	5
COAD	CRTAM →	+0.629	+0.194	<.001	.003	3	4
COAD	NPL →	+0.544	+0.311	<.001	<.001	3	4
GBM	LCP1 →	+1.094	+0.448	<.001	<.001	3	4
LUAD	PTGS2 →	+1.682	+0.192	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050482 vs PLA2G4A — COAD

Explore this scatter interactively →