Arachidonic acid secretion

Across TCGA cell cohorts, RNA activity of the Arachidonic acid secretion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLTC, COL14A1, and FBXO27, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arachidonic acid secretion activity versus CLTC in BREAST (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CLTC →	-1.300	-0.789	<.001	<.001	3	3
BONE	COL14A1 →	-0.915	-0.439	.003	.008	3	3
LUNG_NSCLC_LUSC	FBXO27 →	-2.995	-0.432	.003	.004	1	4
BONE	CEP135 →	-1.283	-0.384	.001	.007	3	2
BLOOD_Leukemia	DENND5B →	-2.133	-0.631	<.001	.009	2	3
BREAST	PHF12 →	-1.213	-0.927	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050482 vs CLTC — BREAST

Explore this scatter interactively →