Amyloid-beta metabolic process

Across TCGA patient cohorts, RNA activity of the Amyloid-beta metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCL_S67, GINS2, and RPL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid-beta metabolic process activity versus NCL_S67 in GBM (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCL_S67 →	-0.748	-0.068	<.001	<.001	3	6
BRCA	GINS2 →	-0.460	-0.034	.002	<.001	3	6
GBM	RPL3 →	-0.359	-0.054	.001	.003	3	6
GBM	RRM2 →	-0.550	-0.039	.002	.006	3	5
OV	CHAF1A_S141 →	-0.628	-0.030	.005	.005	3	5
COAD	CXorf56 →	-0.612	-0.040	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050435 vs NCL_S67 — GBM

Explore this scatter interactively →