Amyloid-beta metabolic process

Across TCGA patient cohorts, RNA activity of the Amyloid-beta metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPH, CSF2RA, and CXCL12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid-beta metabolic process activity versus NCAPH in UCEC (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPH →	-0.528	-0.194	.001	.002	3	6
LSCC	CSF2RA →	+0.425	+0.133	<.001	<.001	3	6
BRCA	CXCL12 →	+1.361	+0.173	<.001	.001	3	5
BRCA	COLEC12 →	+0.891	+0.154	.001	<.001	3	5
BRCA	ZEB2 →	+1.009	+0.197	<.001	<.001	3	5
COAD	CST7 →	+0.784	+0.180	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050435 vs NCAPH — UCEC

Explore this scatter interactively →