Amyloid-beta metabolic process

Across TCGA cell cohorts, RNA activity of the Amyloid-beta metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF286B, GOLGA6L10, and NGRN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid-beta metabolic process activity versus ZNF286B in SOFT_TISSUE (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF286B →	-0.931	-0.226	.002	.004	3	4
SOFT_TISSUE	GOLGA6L10 →	-1.065	-0.287	.004	.001	3	4
SOFT_TISSUE	NGRN →	-0.422	-0.245	.004	.008	3	4
BLOOD_Leukemia	ZBTB26 →	-0.800	-0.289	<.001	.001	3	4
BLOOD_Leukemia	HECTD4 →	-0.629	-0.296	<.001	.002	3	4
BLOOD_Leukemia	FICD →	-0.584	-0.291	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050435 vs ZNF286B — SOFT_TISSUE

Explore this scatter interactively →